Ever wanted to see the activity of the neurons from a almost entire brain ? 10 days ago, Vladimirov et al. described how they have used light-sheet microscopy to record the activity of nearly every neuron in the larval zebrafish brain as the animal responded to sensory stimuli.

You can see it by looking at this wonderfull video.

Light-sheet fluorescence microscopy allow to illuminate a thin slice of the sample, perpendicularly to the direction of the observation.

From Vladimirov, N. et al. Light-sheet functional imaging in behaving zebrafish. Nature Methods doi:10.1038/nmeth.3040 (27 July 2014)