Ever wanted to see the activity of the neurons from a almost entire brain ? 10 days ago, Vladimirov et al. described how they have used light-sheet microscopy to record the activity of nearly every neuron in the larval zebrafish brain as the animal responded to sensory stimuli.
Light-sheet fluorescence microscopy allow to illuminate a thin slice of the sample, perpendicularly to the direction of the observation.
From Vladimirov, N. et al. Light-sheet functional imaging in behaving zebrafish. Nature Methods doi:10.1038/nmeth.3040 (27 July 2014)