Data mining and statistics in HCS need to be improved in order to use this powerful tool in its full capacity of high content. This article is really realistic, as Z’ is always used in HTS but is not relevant for HCS. This article explains us why we need to change our methodologies to be more efficient in HCS, by probably returning to statitistic fundamentals.

source: http://jbx.sagepub.com/content/early/2014/04/04/1087057114528537