Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis.
In this study from Sullivan et al., they show that increased migration in response to Hyaluronic acid (HA) perturbation in cultured cells is dependent on a concomitant increase in glucose metabolism. They propose that ECM remodeling serves as an additional node of acute cell-extrinsic metabolic regulation, one that can directly read out the structural state of the surrounding tissue and augment cell behavior accordingly.
This is a supplementary argument why we chose Hyaluronic acid as a major compound of our technology for 3D cell culture BIOMIMESYS® Hydroscaffold!