Skin microbiota protects their host from oxidative stress through secreted antioxidant RoxP

Many skin diseases, including psoriasis and basal cell carcinoma, are associated with microbial dysbiosis characterized by reduced C. acnes prevalence. C. acnes is a facultative anaerobic bacterium that is frequently found on the human skin. This bacterium is both an opportunistic pathogen and a commensal organism. Indeed, most individuals are Read more…

Développement d’un modèle cérébral in vitro en 3 dimensions (présentation au congrès de la SCMC)

Véronique De Conto, doctorante chez HCS Pharma, présentera ce jeudi 28 mars à Lille, au congrès annuel de la Société Cerveau et Maladies Cérébrovasculaires, le développement d’un modèle cérébral en 3 dimensions incluant le microenvironnement matriciel pour la recherche de nouveaux médicaments contre la maladie de Parkinson. Introduction : 90% Read more…

Influence of the extracellular matrix on cancer cell proliferation and migration

Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…

Cell hyaluronan

Breakdown of the extracellular matrix (ECM) promotes increased cell migration via upregulation of glycolysis

Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis. In this study from Sullivan et al., they show that increased migration in Read more…

BAMM technique. Credit: CNBP

Photobleaching, a great advantage in super-multiplexed fluorescence microscopy!

In a recent article, Dr Antony Orth from the Australian Research Council’s, Centre of Excellence for Nanoscale BioPhotonics (CNBP)  explains how to use the photobleaching phenomenon to increase the potential of fluorescence microscopy. The BAMM technique (bleaching-assisted multichannel microscopy) takes advantage of the rate of photobleaching to identify a fluorophore (instead of Read more…

Ce microscope permet d’observer des cellules vivantes avec des détails impressionnants !

Nous sommes toujours fascinés par les développements de l’imagerie, en particulier les prises de vues en 3D (qui sont au cœur de notre métier). Dans cette article, l’équipe combine la technologie des feuillets de lumière avec l’optique adaptative utilisée normalement en astronomie. Impressionnant ! Pour la première fois, des scientifiques Read more…