A representative hematoxylin and eosin staining of UV-induced skin tumor or skin obtained from SKH-1 mice colonized by S. epidermidis 1457 or MO34, respectively, treated with UV-B for 12 weeks.

A representative hematoxylin and eosin staining of UV-induced skin tumor or skin obtained from SKH-1 mice colonized by S. epidermidis 1457 or MO34, respectively, treated with UV-B for 12 weeks.

Researchers from the Department of Dermatology of the University of California have a commensal strain of Staphylococcus epidermidis that protects against skin neoplasia. This strain produces 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. Mice colonized with this strain have a reduced incidence of ultraviolet-induced tumors compared to control mice (colonized with a control strain, not producing 6-HAP). The strain producing 6-HAP has been found in several healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer.

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Source : http://advances.sciencemag.org/content/4/2/eaao4502.full


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