Researchers from the Department of Dermatology of the University of California have a commensal strain of Staphylococcus epidermidis that protects against skin neoplasia. This strain produces 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. Mice colonized with this strain have a reduced incidence of ultraviolet-induced tumors compared to control mice (colonized with a control strain, not producing 6-HAP). The strain producing 6-HAP has been found in several healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer.
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