Adipose tissue is vitally important to various normal processes of the human body, and it has also many implications for human disease states. Obesity is a common health problem and is considered as a major risk factor for non insulin-dependent diabetes mellitus, cardiovascular diseases and hypertension. Obesity is a well-known risk factor of breast cancer in post-menopausal women that also correlates with a diminished therapeutic response.
The biological significance of 3D cell culture in understanding cellular behavior and function is highlighted by studies with various cell types. Therefore, 3D adipocyte cultures have been developed to better understand the role of adipocytes in adipogenesis and the treatment of obesity or preclinical formulation screening for cosmetic application. BIOMIMESYS® biofunctionalized with collagen type I and VI, represents the only model based on Hyaluronic Acid and a physiological mixture of undenatured collagen I and VI, which is ready-to-use for 3D adipocyte culture. The mechanical properties and the highly porous nature of the matrix allows the rapid uptake of nutrients into the cells, and makes the model compatible with all downstream analyses on 3D adipocyte cultures.