The Santiago Rivera team of Neurobiology Laboratory of cellular interactions and neurophysiopathology, in collaboration with researchers from the universities of Nice-Sophia Antipolis, Montpellier, Munich and Tokyo, demonstrates for the first time the contribution of the MT5-MMP protease in the development of Alzheimer’s disease in a mouse model.
The positive impact of MT5-MMP deficiency was still noticeable at 16 months of age, as illustrated by reduced amyloid burden and gliosis, and a better preservation of the cortical neuronal network and synaptophysin levels in bigenic mice. MT5-MMP expressed in HEKswe cells colocalized and co-immunoprecipitated with APP and significantly increased the levels of Aβ and C99.
Source (in french) : http://www.techno-science.net/?onglet=news&news=14381
To know more (in english) : http://link.springer.com/article/10.1007%2Fs00018-015-1992-1 and http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14864.html