Adipose tissue is vitally important to various normal processes of the human body, and it has also many implications for human disease states. Obesity is a common health problem and is considered as a major risk factor for non insulin-dependent diabetes mellitus, cardiovascular diseases and hypertension. Obesity is a well-known risk factor of breast cancer […]

A staphylococcal infection is a common bacterial skin infection due to staphylococci bacteria. Staphylococcus aureus (S aureus) is part of the nasal microbiome and is the most important of these bacteria in human diseases. About 15–40 per cent of healthy humans are carriers of S aureus, and staphylococcal infection has become a significant public health burden due to infection […]

Le colloque annuel de la Société Cerveau et Maladies Cérébrovasculaires (SCMC) est annoncé dans les locaux de la CAHPP à Paris le 15 mars prochain, avec au programme un mini-symposium « Nanoparticules et cerveau » avec les interventions de Emmnanuel Garcion (« Nanomédecine et cancer aujourd’hui : recherche et enjeux thérapeutiques »), Patrick Couvreur (« Nanoparticles for neurological disorders: to […]

There are many ways to look cells and inside components. At HCS Pharma we know well fluorescent microscopy in “classical” or “confocal” conditions but we are always interesting by others technologies and Cellular seismology is really promising ! In the video from CRCHUM & University of Montréal (Canada) we will see how to observe “cell […]

Yukiko Matsunaga and Fabrice Soncin have developed a human microvessel-on-a-chip that allows to study pro- and anti-angiogenic effects of drugs, and their influence on vascular permeability. This model relies on the establishment of an initial vessel within a collagen-containing matrix, from which angiogenic sprouts will be induced by stimulation of VEGF-A/VEGFR-2 pathway. As in vivo, […]

For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to animal or  human models from […]

Sometime the beauty is just under our eyes, as you can see with this amazing picture of a “ordinary” skin cell from Dr. Bram van den Broek and Andriy Volkov, a student in the Cell Biophysics group at The Netherlands Cancer Institute (NKI). This cell (HaCaT keratinocyte) expresses an excessive amount of keratin (labeled in yellow), ans it is observed […]

Year 2017 has been very busy for us with our implantation in Lille on the Eurasanté Park, the installation of HAPIx (our great automation platform from our great partner Molecular Devices), many presentations at many events (BIOFIT Strasbourg, HCA Boston, SIBS Zurich, Drug Discovery Liverpool, ELRIGfr Monaco, in-cosmetics Global London, Forum Labo Paris, etc.), the strengthening of our scientific partnerships, the internalization of BIOMIMESYS technology and, of course, the development of our amazing team […]

Last week, I was at ELRIGfr meeting in Monaco, as president of RA’pro (Association for the Promotion of Augmented Reality), to chair an augmented reality workshop with famous societies as Molecular Devices, Sopra Steria, agence dad and Microtechnix.  Many other things were of course interesting and, even if I’m not a biologist, I’m happy to […]

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