“While classical screens with a single readout only allow you to quantify the measured effect, high-content screens promise more: Additional phenotypic changes can be observed and also quantified, allowing in principle a distinction of the chemical responses into three classes: similar to untreated cells; similar to control-treated cells; or dissimilar to both.”

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Source: http://www.genengnews.com/insight-and-intelligence/the-renaissance-of-phenotypic-research/77900057/