DNA damage (DNA break, DNA-adduct, epigenetics, …), highly implicated in cancer, can occur under different conditions:
- UV exposure (coupled with UV irradiation for these models)
- Pollution and various external aggressions (Chemical aggression, Smoke, …)
- Natural ageing
HCS Pharma has developed an automated 96-well plate assay for DNA damage protection assessment by using Comet analysis as endpoint.
Here is an example of DNA damage protection by N-Acetylcystein (NAC) against DNA damage induced by H2O2:
This assay allows to test if your molecules or active indegredients have a protection effect on oxidative DNA damage.
If you need more information, don’t hesitate to contact us!