Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical cue that precedes disease and drives its progression by altering cellular behaviors. Targeting extracellular matrix mechanics, by preventing or reversing tissue stiffening or interrupting the cellular response, is a therapeutic approach with clinical potential. Potential pharmacological interventions to overcome extracellular matrix stiffening are emerging clinically. Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.

Source : http://stm.sciencemag.org/cgi/pmidlookup?view=short&pmid=29298864.

In HCS Pharma, We really believe that developing relevant cellular in vitro model close to the in vivo situation is a key point to find new therapeutic drugs in neurodegenerative disease, cardiometabolic disease or in oncology. To implement cellular screening models close to in vivo situation, We use BIOMIMESYS® 3D system, an exclusive and innovative biofunctionalized natural scaffold. If you want to know more on this 3D scaffold system, follow this link or contact us!

HCS Pharma, expert in cellular imaging & in vitro assay development for High Content Screening (HCS) & Analysis (HCA) has just acquired BIOMIMESYS® Technology, a biomimetic hydrogel scaffold based on biofunctionalized hyaluronic acid with extracellular matrix components for 3D cell culture.

If you have already used BIOMIMESYS® products, be aware that they will be available again in early 2018! If you do not know yet this technology, please let us know your interest.

Using BIOMIMESYS® Technology, HCS Pharma will also provide its expertise in HCS/HCA to evaluate the efficacy, mode of action, and safety of your therapeutic molecules on 3D cell models.

Ask us for a TC to know more about our services and products.

BIOMIMESYS® Plates’ assets:

  • Natural biofunctionnalized scaffold
  • Ready-to-use and easy to handle for highly reproducible experiments
  • Compatible with HTS & HCS
  • Use also for long term cultures & in vivo transplantation
  • Ease of cell retrieval, PCR & WB analysis

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