It was the first time HCS Pharma participate at 35th symposium of the French society of genetic toxicology (SFTG) as a sponsor. The implication of the SFTG in the study and assessment of environmental genotoxic agents motive us to be a sponsor of this 35th event.

This year, topic focused on the trans generational genotoxic and epigenetic effects of environmental compounds. Two high level plenary session, presented by Francelyne Marano and Giacomo Cavalli from CNRS, has introduced clearly the different implications of trans generational genotoxicity and epigenetic effects. The role of germinal cells was clearly established in exposition to genotoxic compounds and we were pleased to see clinicians and lab scientists exchanged about this topic.

We also presented our last assay on micronucleus and gamma H2AX detection to the SFTG community. Thanks to the positive feedback received after the presentation, we are confident in the quality and robusteness of our automated genotoxicity assays.

If you want more information about this symposium, you can check the twitter account of the SFTG on @SFTGene

Julian BURSZTYKA participated to the 7th Cosm’ing event, on cosmetic ingredients & biotechnology. He presented a poster on the assessment of genotoxic properties through gammaH2AX and comet assays, by High Content Screening, from a collaborative work done with Galderma. The scientific committee allowed him also to give a short talk about the added value given by using cellular imaging and image analysis while doing research to find better active extracts or pure chemicals in the cosmetic or nutraceutic fields.

As a whole, this 7th Cosm’ing event, organized by CBB-Capbiotek, was a very fruitful one, allowing many very qualitative and interesting discussions.

Quantifying DNA damage is mandatory to assess potential adverse effects of candidate, drugs, molecules or extracts developed in dermo-cosmetic industry. Different assays can be performed to detect primary DNA damages, such as γH2AX or the single cell gel electrophoresis also known as the comet assay. The High Content Imaging technology was used as a valuable tool for screening in early discovery phase.

Four non genotoxic compounds and twelve genotoxic compounds from the ECVAM list I or II were selected to be tested on different cell models.  Preliminary results on Mitomycine C, 4 Nitroquinoline-N-oxide and D-mannitol are shown here.

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