As we said at Forum LABO and ELRIGfr event, we are convinced that many (not-so) new technologies can enhance work of biologists. Augmented reality is a great tool to see “things that are not here” 🙂 It’s exactly why we have used it to check and validate our future robotic platform compliance (in our Lille laboratories) before delivery. Thanks to our partner Molecular Devices, we have worked on the platform 3D model to put it into a Microsoft Hololens and finally, in our laboratory ! The process is not so complex, when you work with Hololens specialists like dad ( !

As you can see on the video below, our CEO Nathalie talks with Cédric (from Molecular Devices) about small modifications on the platform. They see together the same 3D model. It is also possible to add a third person from a distant place.

It was only the first step ! Now we are working on the training part of our project and, of course, the possibility to maintain the platform from anywhere in the world ! If you have question, don’t hesitate to talk with our CDO Grégory, as you can see on his profile he is also an AR expert !

It was a real pleasure to be in the « High-Content and Phenotypic Screening » meeting in Cambridge. We were invited by our partner Molecular Devices to give a talk during the “User meeting Molecular Devices” about our vision of 3D culture in phenotypic screening and the impact of new technologies. We also presented a poster about “Neurotoxicity assay on 2D and 3D culture using High Content Screening technology”.

You can find our presentation here and our poster here.

It was a good opportunity to present our new laboratories in Lille and the future HCS Pharma robotic platform built by Molecular Devices with two ImageXpress Micro confocal.

After a short presentation of our services, we explained our implication in the two research projects InnovCell 3D and Chopin. Many people were interested by these programs,

We also shared again our uses of new technologies like augmented reality, virtual reality or machine learning, like in the previous forum LABO. We noticed that the 3D segmentation is a problem for almost everybody. It will be one of our goal for 2017 to check as many segmentation solutions as possible and to build our own in relation with MetaXpress and Molecular Devices.

If you have any questions, if you want to share about this topic, don’t hesitate to contact us !

3D cell models are now attracting a huge interest from scientists working both on toxicity and pharmacology assay development. They are considered more relevant at mimicking the in vivo situation. However, phenotypic assays on these models can be challenging, and are at least more complex.

A team from Molecular Devices and Cellular Dynamics has worked on the “phenotypic characterization of toxic compound effects on liver spheroids derived from iPSC using confocal imaging an three-dimensional image analyis”. The results have been published September 2016 in Assay and Drug Development Technologies, and describe how the ImageXpress Micro Confocal High-Content Imaging System and MetaXpress High-Content Image and Analysis Software (Molecular Devices) were used to manage the phenotypic characterization.

Assuming that the approach may be extensible to more complex 3D systems, such as cultures containing multiple cell types (e.g., Kuppfer cells, fibroblasts, endothelial cells), they conclude 3D analysis would allow characterization of different cell populations and their roles in toxicity and liver injury.

Source : Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis

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