I was present at the last congress ELRIGfr in Brussels. It was a strong exchange place with interesting presentations around robotics. It is always really interesting to see examples of innovative automation which give really robust results. For example, Frank Gudermann from university of Bielefield in Germany showed that automation of culture cell with cell count by holographic picture gives more robust results as manual count by trypan blue. Or automation of PK sampling with nanoliter by using echo technology allows increasing throughput of bioanalytical analysis for PK studies in Hoffmann La Roche. Also, another presentation of IGR has shown a complete robotic platform with 4 imagers (Micro from MDS) and 1 FACS totally automated from cell seeding to staining and reading.

It was a great pleasure also for us to present 4 different posters on our few last month works in cell imaging. This work was done in collaboration with Perkin Elmer on the Operetta machine. This machine allows us to take images in a 3D culture as shown in these posters: neuroprotection model for parkinson disease and oncology and performed also really nice images showed in these other posters: hepatotoxicity assay and genotoxicity assays.

The Santiago Rivera team of Neurobiology Laboratory of cellular interactions and neurophysiopathology, in collaboration with researchers from the universities of Nice-Sophia Antipolis, Montpellier, Munich and Tokyo, demonstrates for the first time the contribution of the MT5-MMP protease in the development of Alzheimer’s disease in a mouse model.

The positive impact of MT5-MMP deficiency was still noticeable at 16 months of age, as illustrated by reduced amyloid burden and gliosis, and a better preservation of the cortical neuronal network and synaptophysin levels in bigenic mice. MT5-MMP expressed in HEKswe cells colocalized and co-immunoprecipitated with APP and significantly increased the levels of Aβ and C99.

Source (in french) : http://www.techno-science.net/?onglet=news&news=14381

To know more (in english) : http://link.springer.com/article/10.1007%2Fs00018-015-1992-1 and http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14864.html

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