Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, kindle innovation in the development of functional and Biomimetic Materials for engineering the 3D cell microenvironment.

In this review, authors examine emerging and exciting based biomaterials technologies for 3D cell culture. Biomimetic Materials made of a large variety of materials with different composition (ECM compounds), porosities, and mechanical characteristics designed to mimic the microenvironment of specific tissues.

Future directions and technical challenges still remain to produce matrix with in vivo–like complexity for 3D cells-based HTS and HCS for drug discovery.

Source : http://pubs.acs.org/doi/abs/10.1021/acs.chemrev.7b00094

Complexify cell models to improve relevance of the phenotyic assay in order to find new drugs more efficient is that’s what everyone strives to do. To go further, Zebrafish is a whole organism more and more known and used during the process of drug discovery. As reported by MacRae & Peterson in “Zebrafish as tool for drug discovery” published in Nature Review Drus Discovery.

“It has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery.”

But to be usefool, the similarities and differences between human and zebrafish biology need to be understand to  know the limitation of this tool. In this review, an overview of those is made!

 

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