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High troughput in HCS in whole organism is the future?
Complexify cell models to improve relevance of the phenotyic assay in order to find new drugs more efficient is that’s what everyone strives to do.
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Screen Approaching using zebrafish embryos
Here is an interesting video from Department of Biological Sciences, University of Notre Dame, explaining how to do imaging on zebrafish embryos.
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Automation of imaging for in vivo studies
NIH Grant has been awarded to Hudson Robotics and Johns Hopkins University for in vivo Studies. Cell imaging on in vivo studies on whole organism as zebrafish is a powerfull tool during drug discovery. Nevertheless, the throughput is really low to be used during preliminary drug discovery. Working on implementation Read more…
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High Content Screening on whole organism
Before the discovery and development of molecular biology, screening assays to find new drugs was performed on animals. Since the last decade with #high content screening, assays on whole organisms come back in primary screening. In this article, the author have identified 20 potential stimulators of beta-cell replication #in Read more…
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Activity of neurons through live cell imaging
Ever wanted to see the activity of the neurons from a almost entire brain ?