Complexify cell models to improve relevance of the phenotyic assay in order to find new drugs more efficient is that’s what everyone strives to do. To go further, Zebrafish is a whole organism more and more known and used during the process of drug discovery. As reported by MacRae & Peterson in “Zebrafish as tool for drug discovery” published in Nature Review Drus Discovery.

“It has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery.”

But to be usefool, the similarities and differences between human and zebrafish biology need to be understand to  know the limitation of this tool. In this review, an overview of those is made!