Organisms store lipids when they consume more energy than they can use immediately. In mammals, adipose tissue, in addition to its role as an endocrine organ, is specialized in fat storage. Adipose tissue is mainly composed of adipocytes. Until recently, adipocytes were primarily considered mere reservoirs of energy stored as lipid.

However, adipocytes secrete many molecules that are known to regulate processes beyond metabolism. In the skin, their role in the regulation of hair follicle growth and skin epithelia in health and disease might be the first of many previously unknown roles of adipocyte lineage cells in the skin. This layer of adipocytes could participate in thermogenesis, hair cycling, wound healing, fibrosis and scarring, and, most recently, immune defense against infection.

Adipose tissue as a layer is involved in energy storage, thermal insulation, and mechanical support, fat accumulation is associated with negative metabolic and cardiovascular outcomes and cosmetic undesirability. Fat accumulation is determined by the balance between fat synthesis (lipogenesis) and fat breakdown (lipolysis/fatty acid oxidation). Lipogenesis includes the processes of fatty acid synthesis and subsequent triglyceride synthesis.

In order to assess if your active can limit fat accumulation, HCS Pharma offers you an in vitro test on 3T3-L1 adipocytes, allowing you to assess intracellular triglycerides production by fluorescence. This test use caffeine as positive control. See our brochure for more details on this test.

For more information about these tests, please feel free to visit our website or to contact us.


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