BIOMIMESYS® Oncology is a relevant hydroscaffold for cancer-related in vitro studies

BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…

Influence of the extracellular matrix on cancer cell proliferation and migration

Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…

EUROcC (Organ-on-chip) conference in Stuttgart!

The first EUROoC meeting, dealing with organ-on-chip research and organized by the Chemical and Biological Microsystems Society (CBMS), will take place on the 24th-25th of May 2018 in Stuttgart (Germany).  Interestingly, this new workshop will address the engineering challenges related to the design, fabrication and implementation of organ-on-chips (OOC) and microphysiological systems. Among other Read more…

Colloque annuel de la SCMC (Société Cerveau et Maladies Cérébrovasculaires)

Le colloque annuel de la Société Cerveau et Maladies Cérébrovasculaires (SCMC) est annoncé dans les locaux de la CAHPP à Paris le 15 mars prochain, avec au programme un mini-symposium « Nanoparticules et cerveau » avec les interventions de Emmnanuel Garcion (« Nanomédecine et cancer aujourd’hui : recherche et enjeux thérapeutiques »), Patrick Couvreur Read more…