BIOMIMESYS® Oncology is a relevant hydroscaffold for cancer-related in vitro studies

BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…

Influence of the extracellular matrix on cancer cell proliferation and migration

Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…

EUROcC (Organ-on-chip) conference in Stuttgart!

The first EUROoC meeting, dealing with organ-on-chip research and organized by the Chemical and Biological Microsystems Society (CBMS), will take place on the 24th-25th of May 2018 in Stuttgart (Germany).  Interestingly, this new workshop will address the engineering challenges related to the design, fabrication and implementation of organ-on-chips (OOC) and microphysiological systems. Among other Read more…