Studying sprouting angiogenesis and vascular permeability in a 3D human in vitro model

Yukiko Matsunaga and Fabrice Soncin have developed a human microvessel-on-a-chip that allows to study pro- and anti-angiogenic effects of drugs, and their influence on vascular permeability. This model relies on the establishment of an initial vessel within a collagen-containing matrix, from which angiogenic sprouts will be induced by stimulation of Read more…