BIOMIMESYS® is a unique groundbreaking 3D cell culture technology which associates the behavior of a solid scaffold and of a hydrogel. It provides a cell culture microenvironment reproducing all aspects of human tissues, including matrix architecture, cellular organization, cell-cell and cell-matrix interactions.


Depending on the organ, extracellular matrix components and their proportions may vary, allowing a more or less dense and compact cellular environment (different Elastic Moduli, porosities).

BIOMIMESYS® matrices are made of Hyaluronic Acid (HA), the main glycosaminoglycan (GAG) of the ECM, collagens and adhesion proteins. Our patented manufacturing process allows to preserve the natural properties of HA and therefore synthesizing proprietary Hydroscaffold™.

Tuning the composition of BIOMIMESYS® matrix allows to mimic the cellular microenvironment of any organ or tissue of interest.


Collagen IV
Cationic biopolymer

Elastic Modulus 0.10 kPa

Cells already tested

  • Primary cells: astrocytes, neuronal cells
  • Cell lines: SH-SY5Y, SK-N-SH, Luhmes
  • iPSC-derived human neuronal cells

Organization of CNS cells in BIOMIMESYS® Brain

For a better in vitro/in vivo correlation

By using a brain-specific ECM with BIOMIMESYS® Brain, Luhmes cells showed lower sensitivity to Parkinson’s disease inducers in BIOMIMESYS® compared to 2D culture.

BIOMIMESYS® is compatible with all downstream analytical technologies.