BIOMIMESYS® is a unique groundbreaking 3D cell culture technology which associates the behavior of a solid scaffold and of a hydrogel. It provides a cell culture microenvironment reproducing all aspects of human tissues, including matrix architecture, cellular organization, cell-cell and cell-matrix interactions.
Depending on the organ, extracellular matrix components and their proportions may vary, allowing a more or less dense and compact cellular environment (different Elastic Moduli, porosities).
BIOMIMESYS® matrices are made of Hyaluronic Acid (HA), the main glycosaminoglycan (GAG) of the ECM, collagens and adhesion proteins. Our patented manufacturing process allows to preserve the natural properties of HA and therefore synthesizing proprietary Hydroscaffold™.
Tuning the composition of BIOMIMESYS® matrix allows to mimic the cellular microenvironment of any organ or tissue of interest.
HA + RGDS
Elastic Modulus: 0.6 kPa
Cells already tested
Primary human cells: Primary hepatocytes
- Hepatocytes : HepG2/HepaRG
- Stellate: LX2
iPSC-derived human liver organoids or hepatocytes
For a better cell longevity and a proper phenotype
BIOMIMESYS® Liver is dedicated to the culture of liver cells such as hepatocytes. Unlike in 2D culture, primary human hepatocytes in 3D within BIOMIMESYS® Liver had their enzymatic activities (e.g. CYPs) and albumin secretion maintained until 21 days.
For a better in vitro/in vivo correlation
By using a liver-specific ECM with BIOMIMESYS® Liver, steatotic effect on HepaRG cell line is closer to clinical observations.