Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, kindle innovation in the development of functional and Biomimetic Materials for engineering the 3D cell microenvironment.

In this review, authors examine emerging and exciting based biomaterials technologies for 3D cell culture. Biomimetic Materials made of a large variety of materials with different composition (ECM compounds), porosities, and mechanical characteristics designed to mimic the microenvironment of specific tissues.

Future directions and technical challenges still remain to produce matrix with in vivo–like complexity for 3D cells-based HTS and HCS for drug discovery.

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