Our next webinar with Molecular Devices : A physiologically-relevant 3D ECM for in vitro oncology research and intelligent high-content imaging of 3D models

We are very happy to invite you to our next webinar about 3D cellular cancer models and our BIOMIMESYS® Oncology matrix which allows cancer cells to be cultured in a tumor-like environment, with the possibility to tune the composition and stiffness of the matrix. We will also share our best Read more…

Join us at Molecular Devices workshop on innovative 3D methods for HCS, March 16-17, 2021

During the next Molecular Devices online event called “From organoids to cell painting: Investigate 3D and complex biology using advanced methods in high-content cellular imaging and analysis” we will present how to generate functional human liver organoids derived from hiPSC in BIOMIMESYS® hydroscaffold. This virtual user meeting and workshop is Read more…

On the importance of extracellular matrix of the skin for efficient 3D cell culture models

The extracellular components of the skin can be divided into fiber-forming structural molecules, nonfiber-forming structural molecules, and “matricellular proteins”. Optimal quantities of different matrix components and their delicate interactions are necessary to maintain normal physiologic properties of the skin. Fiber-forming molecules provide a structure to the ECM by creating a Read more…

Artificial intelligence to improve 3D cell culture : a milestone for HCS pharma

As you may now, in HCS Pharma we strongly believe that the critical point of the human health evolution in next years is the in vitro 3D cell culture, especially for complex diseases like cancer [1]. It’s why we work hard on our exclusive BIOMIMESYS® technology. As experts in HCS and cell imaging, we must master all the process : 3D biological models, 3D cell culture, volumetric pictures acquisition, 3D reconstruction and segmentation of cells and ECM compounds, 3D parameters extraction and, of course, biological interpretations. As explained in our VisuAI R&D project, the 3D reconstruction and segmentation step is not simple.

Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D

Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate their involvement in cancer pathogenesis, we developed a reticulated HA Read more…

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

A publication from R. Lane et al, described the use of Small extracellular vesicles (sEVs) reservoir as a biomarker for Glioblastoma tumor subtyping. In this publication Astrocytes, Glioblastoma cell lines, and Glioblastoma patient-derived stem cells were grown in BIOMIMESYS® hydroscaffold. Abstract Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options Read more…