Organisms store lipids when they consume more energy than they can use immediately. In mammals, adipose tissue, in addition to its role as an endocrine organ, is specialized in fat storage. Adipose tissue is mainly composed of adipocytes. Until recently, adipocytes were primarily considered mere reservoirs of energy stored as Read more…
Our BIOMIMESYS® Adipose tissue extracellular matrix expands our 3D study possibilities ! HCS Pharma offers you a new 3D test for the evaluation of slimming properties of your actives ingredients. It offers you the possibility to observe the fat-inhibiting potential of your compounds. Adipose tissue is mainly composed of mature Read more…
Follow the webinar « From 2D to 3D » with miss Oceane Guyot, R&D dermarto cosmetology Project leader on ; – Tuesday, April 25, 2023 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) – Thursday, April 27, 2023 – 5PM (CEST) / 11PM (CST) / 12PM (JST) / 11AM Read more…
We will be pleased to meet you in Paris from the 28th to 30th of March. Join Thierry DE CATHEU Business Director, Mathieu LAOUENAN Chief Commercial Officer, Paul COUVREUR and Rita HIEN Junior Business Developpers. Meryl Roudaut, our Project leader in metabolic tissues, and our Project director Elodie VANDENHAUTE will Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). BIOMIMESYS® hydroscaffold technology based on crosslinking Hyaluronic Acid (HA) and extracellular matrix compounds reproduces tissue microenvironment Read more…
When Tuesday, April 26, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, April 28, 2022 – 1PM (CEST) / 7PM (CST) / 8PM (JST) / 7AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as Read more…
Pre-adipocytes differentiate into adipocytes through several phases: differentiation and maturation, where they are then completely functional (lipogenesis / lipolysis).
Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used Read more…
The morphological changes in cells during differentiation are accompanied by a profound change at the molecular level. In vivo, the adipocyte differentiation process includes early and late events due to differential gene regulation. The appearance of these markers is a sign of differentiation of pre-adipocytes and hence the development of Read more…
Triglycerides (TGs) are an efficient form of fatty acids to accumulate as energy reservoirs or as building blocks for membrane lipid synthesis. In adipose tissue, TGs are continuously synthesized during lipogenesis. In order to measure the lipogenesis activity of 3T3-L1 and mature human adipocytes, Adipored™ staining and Perilipin immunocytochemistry were Read more…
As you might know, October is the Breast Cancer Awareness Month, an annual campaign to raise awareness about the impact of breast cancer. Research is the key tool to fight this disease and we are very happy to collaborate with amazing research teams in this fight. Since last year, our Read more…
Adipocytes have a characteristic round morphology in vivo, due to the production of one large lipid vesicles, created by lipogenesis (1). In conventional cell culture, adipocytes cannot acquire this physiological morphology.
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this webinar we will focus on BIOMIMESYS® Adipose Tissue and on the ongoing development of Read more…
When Tuesday, April 20, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, April 22, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as promising tools Read more…
Clinicians and researchers worldwide are actively studying the mechanisms governing the infection of humans by SARS-CoV-2 and its consequences on their health, with the objective is to find effective therapies. We all aknowledge their important role in the current crisis – and in preventing future ones! While respiratory symptoms are Read more…
New results of growing of breast cancer (MCF7 and MCF7-sh-wisp2) cells in BIOMIMESYS® Adipose tissue as a relevant 3D in vitro model, using Keller–Segel PDE system to model chemotactical auto-organization of cells. Abstract Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, Read more…
