Cell hyaluronan

Breakdown of the extracellular matrix (ECM) promotes increased cell migration via upregulation of glycolysis

Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis. In this study from Sullivan et al., they show that increased migration in Read more…

BAMM technique. Credit: CNBP

Photobleaching, a great advantage in super-multiplexed fluorescence microscopy!

In a recent article, Dr Antony Orth from the Australian Research Council’s, Centre of Excellence for Nanoscale BioPhotonics (CNBP)  explains how to use the photobleaching phenomenon to increase the potential of fluorescence microscopy. The BAMM technique (bleaching-assisted multichannel microscopy) takes advantage of the rate of photobleaching to identify a fluorophore (instead of Read more…

Invasion of Staphylococcus aureus on human keratinocytes : from animals to humans

A staphylococcal infection is a common bacterial skin infection due to staphylococci bacteria. Staphylococcus aureus (S aureus) is part of the nasal microbiome and is the most important of these bacteria in human diseases. About 15–40 per cent of healthy humans are carriers of S aureus, and staphylococcal infection has become a significant public Read more…