Veille sur le HCS le HCA et la biologie en général
More and more publications especially in US use 3d printing technology to create hierarchical tissue constructs. Another example on heart is described in this article. After apparition of fablab, we could see apparition of biolabs in the near future. Technologies have been rapidly advancing that will enable researchers to fabricate Read more…
We have just get the keys of our new laboratories, 120 m² area, in the biopole of #rennes, a new building especially for start-up in biotechnology. You are welcome to come, visit us at 6 rue Pierre Joseph Colin and take a coffee ! Dans un contexte économique incertain, le projet Read more…
The Vision Summit interviewed Dr Urban Liebel, co-founder of Acquifer based in Karlsruhe Germany at this year’s NIWeek, on the perspective of development of #hcs machine in the future. This interview tooked place in Austin, Texas at the beginning of August. The development of #next generation HCS machines is possible Read more…
Dr. Kim remarked, “Our research is significant in that we presented a candidate material for a new drug for #diabetes without side effects.” He added, “We will try hard to develop a new drug for type 2 diabetes through a follow-up study using automated equipment for high-content screening recently built Read more…
#hcs by multiplexing assays on #3d cell culture have many advantages to find more efficient new drugs for #cancer treatment. Progress in the IT part, on softwares, on the uses on big data and in the machine on speed and sensitivity allow to do multiplexing assays in HCS . This article Read more…
Before the discovery and development of molecular biology, screening assays to find new drugs was performed on animals. Since the last decade with #high content screening, assays on whole organisms come back in primary screening. In this article, the author have identified 20 potential stimulators of beta-cell replication #in Read more…
In this presentation, Dr. Kamyar Hadian (head of the #assay development and Screening Platform’ at the HelmholtzZentrum München in Munich/Germany) talk about #hcs use in #stem cell– and microtissue-based assays. #phenotypic screening has highly emerged in the past years. Especially High-Content Screening (HCS) has gained strong acceptance in the field Read more…
marketreports.com publish a report on hts development and potential market in 3 next years. This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014 … Curated from marketreports.com
Studying motility by time-lapse imaging cells is often time consuming and low throuput. This article shows how increasing throuput on this kind of assay with open source software.
Perkin Elmer is one of the leader in HCS equipment and furniture. To increase the quality of the results in cellular imagery, they have launched a new 384-well microplate : CellCarrier™ Ultra 384-well microplates. We are really excited to test them!
Ever wanted to see the activity of the neurons from a almost entire brain ?
Interestingly, the lab suppliers constantly improve HCS tools, the hard and the software. After the launch of Opera Phenics from Perkin at the beginning of this year, the new CeLLInsight CX5 HCS Platform from ThermoFisher is now available. This HCS platform offers speed, flexibility and efficiency for large-scale, high-throughput biology, including complex morphological Read more…
Genetic Engineering & Biotechnology News (GEN) organise a free webinar about HCS ans HCA use in drug toxicity and genotoxicity testing. High-content analysis (HCA) and high-content screening (HCS) enable imaging of large numbers of cellular samples for a variety of life science applications. Using automated high-resolution microscopy coupled with analytical Read more…
This article highlights the value of high-content imaging in GPCR drug discovery efforts and emphasize the value of a multiassay approach to study pharmacological properties of compounds of interest.
Perkin Elmer and integromics worked together to create a new tools for HCS data analysis by integrating The High Content Profiler software into the visualisation tools already used by a lot of people in pharmaceutical industry: the TIBCO spotfire. This new solution will be presented for the first time next week in Read more…
The Scottish Government believes in the new strategy of phenotypic screening rather than target screening since they invest £8 million for university of Dundee and as they said: “Phenotypic screening is thought to be a powerful method for drug discovery because it offers the opportunity to go beyond the focus on single drug Read more…
Data mining and statistics in HCS need to be improved in order to use this powerful tool in its full capacity of high content. This article is really realistic, as Z’ is always used in HTS but is not relevant for HCS. This article explains us why we need to change Read more…
High throughput and high content screening of compounds that influence cell invasion can be easily performed as you can see in this exemple: source: http://being-bioreactive.com/2014/04/09/a-96-well-invasion-assay-compatible-with-high-content-screening/
As oncology is the first used in HCS, Perkin Elmer has developped new High Content Analysis Platform dedicted for Cancer Applications as you can see below: source: http://www.businesswire.com/news/home/20140407005786/en/Content-Screening-Platform-Advances-High-Content-Analysis-Cancer#.U1OZnPl_tTw
“A new high-content screening software platform enables cancer researchers to uncover more about basic and advanced cellular function to accelerate cell-based research. The Thermo Scientific HCS Studio 2.0 is a high-content quantitative imaging and analysis software platform for a range of cancer research applications, including angiogenesis and migration/invasion, as well Read more…
Non-invasive cancer- diagnosis: a new application for HCS HCS was first used in pharmaceutical industry to develop a new way to find new drugs. But this technology is extended since few years in other domains, as diagnosis! source: http://www.int.laborundmore.de/news/694729/A-new-application-for-microscopy.html
If you want to learn more about HCS/HCA, go and listen this interesting video from MDS: http://cnpg.comparenetworks.com/154049-Leveraging-the-Value-of-Automated-High-Content-Screening/
“While classical screens with a single readout only allow you to quantify the measured effect, high-content screens promise more: Additional phenotypic changes can be observed and also quantified, allowing in principle a distinction of the chemical responses into three classes: similar to untreated cells; similar to control-treated cells; or dissimilar Read more…