The extracellular components of the skin can be divided into fiber-forming structural molecules, nonfiber-forming structural molecules, and “matricellular proteins”. Optimal quantities of different matrix components and their delicate interactions are necessary to maintain normal physiologic properties of the skin. Fiber-forming molecules provide a structure to the ECM by creating a Read more…
We are pleased and proud to welcome Dr Philippe Manivet and Dr Anthony Trezeibre in our Scientific Advisory Board. We are developing new innovative projects with them around our BIOMIMESYS technology. Because our BIOMIMESYS technology is requested in different fields and we want to stay at the forefront of innovation, Read more…
As a Biomaterials research engineer, you will be valued member of a R&D team focused on the development of cell culture biomaterials from discovery stage to scale up. This role will involve taking significant ownership over the design, generation, and testing of biomaterials customized for cellular biology application. By working Read more…
When Tuesday, February 23, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, February 25, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently as promising Read more…
We wish you a great year 2021, with great success in your all your projects. Here at HCS Pharma, we strongly believed that 3D cell culture in adequat medium is a key factor for successful drug discovery projects. To help you as efficiently as possible we have modified this website. Read more…
Step by step we are getting closer to 2021, after a very particular and, for some of us, very difficult 2020 year. 2021 will be THE year of 3D cell culture in many research applications such as drug discovery for complex diseases or cancers. We will be happy to facilitate Read more…
Clinicians and researchers worldwide are actively studying the mechanisms governing the infection of humans by SARS-CoV-2 and its consequences on their health, with the objective is to find effective therapies. We all aknowledge their important role in the current crisis – and in preventing future ones! While respiratory symptoms are Read more…
The job offer in english is available here Dans le cadre de notre développement, nous recrutons un chef de projet (H/F) en oncologie pour mener les projets de R&D et les études clients dans le domaine. L’accent sera mis en particulier sur le microenvironnement tumoral, en travaillant sur l’aspect matrice Read more…
L’offre d’emploi en français est disponible ici As part of our development, we are looking for an oncology project manager (M/F) to lead R&D projects and client studies in the field. Particular emphasis will be given to the tumor microenvironment, working on the extracellular matrix aspect using BIOMIMESYS®, our 3D Read more…
We are very pleased to announce that Meryl, our first CIFRE PhD student, defended his doctoral thesis last week! His PhD work was dealing with the use of pluripotent stem cells to study liver diseases. He has also developed an innovative model to obtain liver organoïds in our BIOMIMESYS® product. Read more…
Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and the extracellular matrix (ECM), plays several roles in health and Read more…
HCS Pharma is pleased to present the whole range of BIOMIMESYS® Products. All our scientific team is ready to support you in using our 3D organ/tissue-specific cell-culture technology. Rediscover your cells in real in vitro 3D-culture conditions with our special evaluation plate format . You can find our presentation in Read more…
Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads to a decrease in the neurotransmitter dopamine that cause mainly Read more…
In 2018, the World Health Organization announced 9.6 million deaths due to cancer, worldwide. Concerning the cancer cost, it was estimated to be more than US$ 1.16 trillion. For these reasons, developing more effective anti-cancer molecules is primordial. Unfortunately, despite the large number of molecules tested, 43% of failure occurs Read more…
As you may know, HCS Pharma makes use of Fluorescence Microscopy to perform biological assays and to test customers’ compounds. We often have questions about this technology, whether it is different or not from optical microscopy, and what it offers in terms of analysis. In a series of short articles, Read more…
Kaur et al. published in 2018 an interesting article about the effect of extracellular matrix (ECM) on skin cancer and immunity: “Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility”. The aim of the study was to highlight ECM changes in the physical Read more…
On the occasion of the breast cancer awareness month, HCS Pharma is willing to thank all researchers working in the field to better understand the pathophysiology of disease, with the objective to find more efficient anti-cancer therapies. We would like to warmly thank the researchers with whom we are collaborating Read more…
Vaihere Cheung obtained her technology A-level (STL) in 2018 at La Mennais, in French Polynesia. Then she came to metropolitan France to reach a technician diploma in Biological engineering, specialized in biological and biochemical analysis, at the University of Lyon. During her studies, Vaihere did an internship in HCS Pharma Read more…
At the occasion of the Breast Cancer Awareness Month, we would like to highlight the role of the interplay between the extracellular environment and the Cancer-Associated Fibroblasts (CAFs) on the tumoral development, including breast cancers. In our previous articles, we described the pro-tumoral effect of the extracellular environment. Moreover, an Read more…
There are 90% of failure in clinical trials, mainly due to safety and efficiency issues. In particular, the central nervous system is involved in 34% of failure in clinical trials, but only in 7% of failure in preclinical trials (Cook et al., 2014). That points a lack of relevance in Read more…
It’s pleasure to welcome Thomas in our team. After a four-month internship at the CrCHUM (Centre de recherche du Centre Hospitalier de l’Université de Montréal, Canada) in the field of microfluidic personalized medicine for prostate cancer, he joined us in September for a six- months-internship, as part of his Master’s Read more…
Cells and the extracellular matrix (ECM): what is the relationship between them? This is a fundamental question. We hear many reflections about this question. Should we let cells work alone, or should we force cells to form an aggregate when working in vitro? Do cells need a specific and relevant Read more…
We are really proud to work on a real partnership with the team of Tokyo Future Style (TFS) Taïwan for almost a year now. Joseph Chou, member of our business advisory board and Pr John Lo, member of our scientific advisory board, have fully understood the value of BIOMIMESYS® our Read more…