Genetic Engineering & Biotechnology News (GEN) organise a free webinar about HCS ans HCA use in drug toxicity and genotoxicity testing. High-content analysis (HCA) and high-content screening (HCS) enable imaging of large numbers of cellular samples for a variety of life science applications. Using automated high-resolution microscopy coupled with analytical Read more…
This article highlights the value of high-content imaging in GPCR drug discovery efforts and emphasize the value of a multiassay approach to study pharmacological properties of compounds of interest.
Perkin Elmer and integromics worked together to create a new tools for HCS data analysis by integrating The High Content Profiler software into the visualisation tools already used by a lot of people in pharmaceutical industry: the TIBCO spotfire. This new solution will be presented for the first time next week in Read more…
The Scottish Government believes in the new strategy of phenotypic screening rather than target screening since they invest £8 million for university of Dundee and as they said: “Phenotypic screening is thought to be a powerful method for drug discovery because it offers the opportunity to go beyond the focus on single drug Read more…
Data mining and statistics in HCS need to be improved in order to use this powerful tool in its full capacity of high content. This article is really realistic, as Z’ is always used in HTS but is not relevant for HCS. This article explains us why we need to change Read more…
High throughput and high content screening of compounds that influence cell invasion can be easily performed as you can see in this exemple: source: http://being-bioreactive.com/2014/04/09/a-96-well-invasion-assay-compatible-with-high-content-screening/
The 11th High Content Analysis conference will take place at the Fira Barcelona, on May 14th & 15th 2014 and Julian will be present in this event. Thus don’t hesitate to meet him during this event! Have a nice congress! Source: http://selectbiosciences.com/conferences/index.aspx?conf=HCA2014
As oncology is the first used in HCS, Perkin Elmer has developped new High Content Analysis Platform dedicted for Cancer Applications as you can see below: source: http://www.businesswire.com/news/home/20140407005786/en/Content-Screening-Platform-Advances-High-Content-Analysis-Cancer#.U1OZnPl_tTw
“A new high-content screening software platform enables cancer researchers to uncover more about basic and advanced cellular function to accelerate cell-based research. The Thermo Scientific HCS Studio 2.0 is a high-content quantitative imaging and analysis software platform for a range of cancer research applications, including angiogenesis and migration/invasion, as well Read more…
Non-invasive cancer- diagnosis: a new application for HCS HCS was first used in pharmaceutical industry to develop a new way to find new drugs. But this technology is extended since few years in other domains, as diagnosis! source: http://www.int.laborundmore.de/news/694729/A-new-application-for-microscopy.html
If you want to learn more about HCS/HCA, go and listen this interesting video from MDS: http://cnpg.comparenetworks.com/154049-Leveraging-the-Value-of-Automated-High-Content-Screening/
“While classical screens with a single readout only allow you to quantify the measured effect, high-content screens promise more: Additional phenotypic changes can be observed and also quantified, allowing in principle a distinction of the chemical responses into three classes: similar to untreated cells; similar to control-treated cells; or dissimilar Read more…
Using automated high content screening and sophisticated computational modeling, the researchers’ screening and analysis of tens of millions of genetically manipulated cells helped them identify more than a dozen genes that influence cell shape. To go more in details of this article, follow this link.