Have you missed our last webinar with Molecular Devices about 3D oncology models? In April, our project leader Elodie was talking about how to establish and image physiologically relevant 3D cancer in vitro models, using BIOMIMESYS Oncology as a surrogate for the tumoral extracellular matrix. Our product BIOMIMESYS® Oncology matrix Read more…
Pharmaceutical industry is facing a very high failure rate in drug discovery, with 90% of failure in clinical trials. This is particularly true for central nervous system applications, with a rate of 30% safety failure in clinical trials, compared to 7% in preclinical trials (Cook et al. 2014). This reveals Read more…
Ask for high quality link by putting your email below There is a 90% failure in clinical trials, due to efficacy and safety issues, which frequently concerns the central nervous system. That points a lack of relevance of preclinical models used upstream. In this frame, the aim of this study Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this webinar we will focus on BIOMIMESYS® Adipose Tissue and on the ongoing development of Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this presentation we will focus on BIOMIMESYS® Liver and will discuss about its different applications. Read more…
3D cell culture systems have recently as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). Join us for this webinar to know more about BIOMIMESYS® technology, our 3D cell culture system designed Read more…
Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate their involvement in cancer pathogenesis, we developed a reticulated HA Read more…
A publication from R. Lane et al, described the use of Small extracellular vesicles (sEVs) reservoir as a biomarker for Glioblastoma tumor subtyping. In this publication Astrocytes, Glioblastoma cell lines, and Glioblastoma patient-derived stem cells were grown in BIOMIMESYS® hydroscaffold. Abstract Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options Read more…
New results of growing of breast cancer (MCF7 and MCF7-sh-wisp2) cells in BIOMIMESYS® Adipose tissue as a relevant 3D in vitro model, using Keller–Segel PDE system to model chemotactical auto-organization of cells. Abstract Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, Read more…
Growing interest in phenotypic screening, together with evidence that the drug response of cells grown in three-dimensional (3D) structures more closely resembles in vivo activity, has made high throughput, 3D fluorescence imaging an attractive screening option for drug discovery. However, creating 3D spheroids compatible with high content screening can be Read more…
We are very pleased to announce that Meryl, our first CIFRE PhD student, defended his doctoral thesis last week! His PhD work was dealing with the use of pluripotent stem cells to study liver diseases. He has also developed an innovative model to obtain liver organoïds in our BIOMIMESYS® product. Read more…
This summer, Vitali et al. published an article in the Open Access Journal Cancers in which they assessed anticancer combination to treat neuroendocrine tumors (NETs) using in vitro models (2D + 3D cultures in BIOMIMESYS hydroscaffolds). A NET arises in the specialized cells of the neuroendocrine system, which have traits of Read more…
As we are involved in some very interesting projects, we have the chance to work with amazing specialists in many field. All these people help us to make the BIOMIMESYS® technology better, easier to use and well adapted to their work. We asked them to explain why they use BIOMIMESYS® Read more…
It’s a great pleasure to present you this discussion with Dr Cécile Legallais about her use of BIOMIMESYS® technology. We thank her for her time and her disponibility despit the COVID-19 lockdown. You can find below the translation in French and English (and you can change captions on the video) Read more…
Abstract The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug. The ATP Binding Cassette transporter A1 (ABCA1) effluxes isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population Read more…
Just before Covid-19 pandemic crisis widely spread to France, we attended the User Meeting organized by Molecular Devices in Hilton Garden Inn Leiden (Oegstgeest, Netherlands). We enjoyed the programme, gathering a variety of topics but with high content analysis/screening as a common technique to answer diverse scientific questions. On the Read more…
In this video, Dr Karim Si-Tayeb explains how he uses BIOMIMESYS® in his research. We want to thank him! You can find below the translation in French and English (and you can change captions on the video). English (French is below) Hi my name is Karim Si-Tayeb I’m a researcher at Read more…
We warmly thanks Dr Samuel Meignan for this short talk about BIOMIMESYS®. You can find below the translation in French and English (and you can change captions on the video). English (French is below) I’m Dr. Samuel Meignan I’m a researcher in biology, specialized in cancerology, and I’m the head Read more…
It was a real pleasure for us to be invited at the last West Data Festival, to present our last developments in Artificial Intelligence dedicated to picture analysis. We warmly thank the organizers, Laval Mayenne Technopole and ATLANPOLE biotérapies for this opportunity. We also thank Laval Virtual to help us Read more…
We often talk about our innovative product BIOMIMESYS® here to explain how we (and others!) us it in many cases. You can imagine that 3D cell culture with this product is complicated or that you have to spend a lot of time in training. But it’s actually quite simple to Read more…
In this tutorial you will see how to seed a BIOMIMESYS® plate with a VIAFLO 384 from INTEGRA Biosciences (https://www.integra-biosciences.com/france/en/electronic-pipettes/viaflo-96384)
In this tutorial you will see how to seed a BIOMIMESYS® plate with a manual multipipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a automatic multipipette