The Building Biology in 3D symposium of the Society for Laboratory Automation and Screening (SLAS) took place in Cambridge, United Kingdom, on March 20th and 21th 2023.
This congress was the opportunity to discover the dynamic scientific environment of Cambridge. Because this event was focusing on 3D cell culture, most presentations were about spheroïds/organoïds development, and how to analyze the results from 3D cell culture, including by imaging. The importance of the extracellular matrix was sometimes discussed, in particular in the opening keynote speech of Göran Landberg about the use of patient-derived scaffold to study breast cancer. On the other hand, lots of models are still in matrix-free systems, or in a non-physiological matrices, whereas more and more studies highlight that the matrix is a key element in the development, in physiological functions, and in pathological mechanisms.
Our Project Leader in in vitro pharmacology Veronique De Conto presented 2 posters about BIOMIMESYS®, an organ-specific matrix for 3D cell culture, and its applications in oncology and in neurosciences:
– 3D cell culture taking into account the extracellular matrix for bridging the gap between in vitro & in vivo: focus on cancer models
– 3D cell culture taking into account the extracellular matrix for phenotypic screening in the frame of Parkinson’s disease
These posters have initiated numerous interesting discussions about the importance to consider the extracellular matrix in in vitro models, as well as the organ specificity and the pathological state of the matrix.
During this congress, Veronique had the pleasure to meet again our partner Molecular Devices. We are happy to use their imaging robotic platform for High Content Screening in BIOMIMESYS® 3D matrix. Together, we can better select drug candidates to improve the clinical success rate.
Warm thanks to the organizers for this very interesting event!
Feel free to contact us if you need more information about BIOMIMESYS® matrix (Oncology, Brain, Liver or Adipose tissue), or about our services in phenotypic screening!