Organoids are three-dimensional structures made of cells, which can be derived from stem cells to mimic the structure and function of real organs. They are useful tools for studying human development, disease modeling, drug screening, and personalized medicine.
Recent advancements in organoid research have focused on improving their complexity and functionality. Scientists have developed organoids of various organs, including the brain, liver, pancreas, lung, kidney, and intestine. These advances have enabled researchers to study complex diseases, such as Alzheimer’s, cancer, and cystic fibrosis, in ways that were not previously possible.
In the future, organoids might be used for regenerative medicine and organ transplantation, providing a potential solution to the shortage of donor organs.
Extracellular matrix is a very important element in the development of complex diseases such as NASH (non-alcoholic steatohepatitis) and later, fibrosis. Therefore, it is important to take into account and implement the right extracellular environment in organoid models. At HCS Pharma, we have developed a liver organoid model (Figure below), by using BIOMIMESYS® and with the aim to go further with a NASH model.
Feel free to contact us if you want more information about BIOMIMESYS® matrix provided in ready-to used multi-well plates, or about our services in pharmacological assessments in 3D by cellular imaging!