Before the discovery and development of molecular biology, screening assays to find new drugs was performed on animals. Since the last decade with , assays on whole organisms come back in primary screening.

In this article, the author have identified 20 potential stimulators of beta-cell replication on transgenic line.

This study establishes a proof of principle for a high-throughput small molecule-screen for beta-cell proliferation in vivo, and identified compounds that stimulate beta-cell proliferation and regeneration.

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