Increase culture time in BIOMIMESYS® Liver

BIOMIMESYS® Liver recreates the complex cellular microenvironment of the liver to extend longevity and functionality of hepatocytes in culture:

• The life of human primary hepatocytes grown in a 2D sandwich is low, 3-10 days (1) and is accompanied by dedifferentiation, leading to the loss of their functions.
• In 2D culture, HepG2 due their ability to proliferate quickly, reach confluence and have low hepatocyte functions limiting their use for metabolic studies or drug induced liver injury, DILI (2)

Therefore, a culture in BIOMIMESYS® Liver:

• Doubles the human primary hepatocytes viability compared to a 2D culture.
• Allows HepG2 to grow without impairing the viability and morphology for at least 4 weeks.