Maintain hepatocyte functions with BIOMIMESYS® Liver

Maintaining the basal characteristics of primary hepatocytes and HepG2 allows performing metabolic studies. The functional instability of hepatocytes in 2D culture results in a rapid decrease in specific metabolic pathways (Figure 1). Cell culture in BIOMIMESYS® Liver shows higher metabolic characteristics of hepatocytes compared to a culture in 2D, such as:

• The albumin secretion, often used as a marker for functionality.
• The presence of active bile ducts (MRP2 and CFDA staining).
• The expression of genes encoding transporters (NTCP, BSEP and MRP2) and phase I enzymes (CYPs)
• and II (UGT) of drugs metabolism.