Maintaining the basal characteristics of primary hepatocytes and HepG2 allows performing metabolic studies. The functional instability of hepatocytes in 2D culture results in a rapid decrease in specific metabolic pathways (Figure 1). Cell culture in BIOMIMESYS® Liver shows higher metabolic characteristics of hepatocytes compared to a culture in 2D, such as:

  • The albumin secretion, often used as a marker for functionality.
  • The presence of active bile ducts (MRP2 and CFDA staining).
  • The expression of genes encoding transporters (NTCP, BSEP and MRP2) and phase I enzymes (CYPs)
  • and II (UGT) of drugs metabolism.

Grégory MAUBON

Grégory MAUBON is Chief Data Officer and digital coordinator at HCS Pharma, a biotech startup focused in high content screening and complex diseases. He manages IT missions and leads digital usages linked to company needs. He is also a Augmented Reality Evangelist (presenter and lecturer) since 2008, where he created and founded in 2010 RA'pro (the augmented reality promotion association). He helped many companies (in several domains) to define precisely their augmented reality needs and supported them in the implementation.


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