The Santiago Rivera team of Neurobiology Laboratory of cellular interactions and neurophysiopathology, in collaboration with researchers from the universities of Nice-Sophia Antipolis, Montpellier, Munich and Tokyo, demonstrates for the first time the contribution of the MT5-MMP protease in the development of Alzheimer’s disease in a mouse model.

The positive impact of MT5-MMP deficiency was still noticeable at 16 months of age, as illustrated by reduced amyloid burden and gliosis, and a better preservation of the cortical neuronal network and synaptophysin levels in bigenic mice. MT5-MMP expressed in HEKswe cells colocalized and co-immunoprecipitated with APP and significantly increased the levels of Aβ and C99.

Source (in french) :

To know more (in english) : and


Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.