New Technique Visualizes Whole Cells at Super-Resolution

Ralf Jungmann, Ph.D., an alumnus of the Wyss Institute and currently a Professor of Biochemistry at the Ludwig Maximilian University (LMU) and the Max Planck Institute (MPI) in Germany and Wyss Institute Core Faculty member Peng Yin, Ph.D. have been developing DNA-PAINT, a powerful molecular imaging technology that involves transient DNA-DNA interactions to accurately localize fluorescent dyes with super-resolution.

Jungmann’s and Yin’s teams jointly work to the adaptation of DNA-PAINT to confocal microscopes. With this combination, visualization of cell internal becomes amazing!

“Our new approach, SDC-PAINT, integrates the versatile super-resolution capabilities of DNA-PAINT with the optical sectioning features of confocal microscopes. We thus created the means to explore the entire depth of a cell, and to visualize the molecules within it at the nanometer scale.”

Source: New Technique Visualizes Whole Cells at Super-Resolution