Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate Read more…
We wish you a great year 2021, with great success in your all your projects. Here at HCS Pharma, we strongly believed that 3D cell culture in adequat medium is a key factor for successful drug discovery projects. To help Read more…
Step by step we are getting closer to 2021, after a very particular and, for some of us, very difficult 2020 year. 2021 will be THE year of 3D cell culture in many research applications such as drug discovery for Read more…
A publication from R. Lane et al, described the use of Small extracellular vesicles (sEVs) reservoir as a biomarker for Glioblastoma tumor subtyping. In this publication Astrocytes, Glioblastoma cell lines, and Glioblastoma patient-derived stem cells were grown in BIOMIMESYS® hydroscaffold. Abstract Glioblastoma (GBM) is one Read more…
Clinicians and researchers worldwide are actively studying the mechanisms governing the infection of humans by SARS-CoV-2 and its consequences on their health, with the objective is to find effective therapies. We all aknowledge their important role in the current crisis Read more…
New results of growing of breast cancer (MCF7 and MCF7-sh-wisp2) cells in BIOMIMESYS® Adipose tissue as a relevant 3D in vitro model, using Keller–Segel PDE system to model chemotactical auto-organization of cells. Abstract Three-dimensional cultures of cells are gaining popularity as an in Read more…
Growing interest in phenotypic screening, together with evidence that the drug response of cells grown in three-dimensional (3D) structures more closely resembles in vivo activity, has made high throughput, 3D fluorescence imaging an attractive screening option for drug discovery. However, Read more…
We are very pleased to announce that Meryl, our first CIFRE PhD student, defended his doctoral thesis last week! His PhD work was dealing with the use of pluripotent stem cells to study liver diseases. He has also developed an Read more…
HCS-Pharma is pleased to launch BIOMIMESYS® Liver and Oncology in ready-to-use 384-well plate format for screening applications. Adopt BIOMIMESYS® 3D cell culture systems and obtain more predictive in vitro models. You can find our presentations in PDF format for BIOMIMESYS® Read more…
Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and Read more…
HCS Pharma is pleased to present the whole range of BIOMIMESYS® Products. All our scientific team is ready to support you in using our 3D organ/tissue-specific cell-culture technology. Rediscover your cells in real in vitro 3D-culture conditions with our special Read more…
Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads Read more…
In 2018, the World Health Organization announced 9.6 million deaths due to cancer, worldwide. Concerning the cancer cost, it was estimated to be more than US$ 1.16 trillion. For these reasons, developing more effective anti-cancer molecules is primordial. Unfortunately, despite Read more…
As you may know, HCS Pharma makes use of Fluorescence Microscopy to perform biological assays and to test customers’ compounds. We often have questions about this technology, whether it is different or not from optical microscopy, and what it offers Read more…
Kaur et al. published in 2018 an interesting article about the effect of extracellular matrix (ECM) on skin cancer and immunity: “Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility”. The aim of Read more…
On the occasion of the breast cancer awareness month, HCS Pharma is willing to thank all researchers working in the field to better understand the pathophysiology of disease, with the objective to find more efficient anti-cancer therapies. We would like Read more…
Vaihere Cheung obtained her technology A-level (STL) in 2018 at La Mennais, in French Polynesia. Then she came to metropolitan France to reach a technician diploma in Biological engineering, specialized in biological and biochemical analysis, at the University of Lyon. Read more…
At the occasion of the Breast Cancer Awareness Month, we would like to highlight the role of the interplay between the extracellular environment and the Cancer-Associated Fibroblasts (CAFs) on the tumoral development, including breast cancers. In our previous articles, we Read more…
There are 90% of failure in clinical trials, mainly due to safety and efficiency issues. In particular, the central nervous system is involved in 34% of failure in clinical trials, but only in 7% of failure in preclinical trials (Cook Read more…
It’s pleasure to welcome Thomas in our team. After a four-month internship at the CrCHUM (Centre de recherche du Centre Hospitalier de l’Université de Montréal, Canada) in the field of microfluidic personalized medicine for prostate cancer, he joined us in Read more…
Cells and the extracellular matrix (ECM): what is the relationship between them? This is a fundamental question. We hear many reflections about this question. Should we let cells work alone, or should we force cells to form an aggregate when Read more…
We are really proud to work on a real partnership with the team of Tokyo Future Style (TFS) Taïwan for almost a year now. Joseph Chou, member of our business advisory board and Pr John Lo, member of our scientific Read more…
This summer, Vitali et al. published an article in the Open Access Journal Cancers in which they assessed anticancer combination to treat neuroendocrine tumors (NETs) using in vitro models (2D + 3D cultures in BIOMIMESYS hydroscaffolds). A NET arises in the Read more…
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