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As shown by AstraZeneca in nature reviews, one third of the safety failures is linked to CNS toxicity during the clinical trials of drugs . To avoid this attrition, the potential neurotoxicity of any drug going through the blood brain barrier (BBB) needs to be checked and if possible at the early stage of the research process for new chemical entites (NCE). This assay can be performed by cell imaging in HCA/HCS.
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