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As shown by AstraZeneca in Nature reviews*, one third of the safety failures is linked to CNS toxicity during the clinical trials of drugs. Therefore, relevant in vitro human models are needed to detect early neurotoxicity of drug candidates. In this study, sensitivity of iPSC-derived neuronal cells to 32 compounds was compared to the sensitivity of differentiated SH-SY5Y cells. Two types of iPSC-derived cells were tested: central nervous system cells (CNS.4U® cells) and peripheral nervous system cells (PERI.4U® cells) from Ncardia. Toxic effects were then measured using HCS cell imaging.
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