Wounds can exhibit impaired healing, as a consequence of pathologic failure to process one of the normal stage of healing. Wound healing impairment could be characteristic of the treatments of chronic wounds due to immobilisation, diabetes, and skin infection. Characterization of compounds efficacy on wound healing parameters is important dermato cosmetology, including scar elimination, anti-aging and aesthetic cosmetics and much more.
The mouse is the most commonly used model in vivo, despite differences in murine and human skin reparation mechanism make it difficult to bridge the gap between preclinical and clinical studies.
Zomer et al have recently publiched in the Journal of Dermatological Science a review highlighting the particulaties of each species which could help you to decide studying wound mechanism in in in vitro human model.
Zomer HD, Trentin AG.
J Dermatol Sci. 2018 Apr;90(1):3-12. doi: 10.1016/j.jdermsci.2017.12.009. Epub 2017 Dec 26. Review.
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