The project
Face to the high failure of drug candidate in clinical trial, in particular involving the brain, we goal to develop more relevant and more predictive in vitro models for preclinical assessment, in the aim to early select molecules of interest, in term of efficacy and safety. For that, we develop cerebral in vitro models in 3 dimensions, including the microenvironment, thanks your technology BIOMIMESYS®, which mimic the extracellular matrix.
What we bring to the partnership
We develop relevant cerebral in vitro model, including:
- Several cerebral cell types, in particular neurons and glial cells, to take into account cell-cell interaction, for example to study neuro-inflammation
- A chemical defined media, for a good reproducibility
- 3 dimensions organization, to better mimic cerebral tissue
- The matricial microenvironment thanks our technology BIOMIMESYS® Brain, a functionalized acid hyaluronic-based hydroscaffold which mimic the brain extracellular matrix.
These models are available in 96 and 384 well plates, compatible with our robotic platform for High Content Screening.
List of partners
- BPI
- Inserm Unit 1171
- HCS pharma