Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used for in vitro studies as well as in obesity animal models. This molecule reduces lipid accumulation by adipocytes and attenuates dysfunctions related to lipid metabolism (2).

Lipolysis allows functional adipocytes to provide energy to other organs through hydrolysis of triglycerides stored in lipid vesicles, releasing fatty acids and glycerol. This process can be regulated by hormonal and biochemical signals acting on lipolytic enzymes (3). Isoprenalin and Caffeine are well-known regulators of lipolysis (4-6).

Grégory MAUBON

Grégory MAUBON is Chief Data Officer and digital coordinator at HCS Pharma, a biotech startup focused in high content screening and complex diseases. He manages IT missions and leads digital usages linked to company needs. He is also a Augmented Reality Evangelist (presenter and lecturer) since 2008, where he created and founded in 2010 RA'pro (the augmented reality promotion association). He helped many companies (in several domains) to define precisely their augmented reality needs and supported them in the implementation.


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