Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used for in vitro studies as well as in obesity animal models. This molecule reduces lipid accumulation by adipocytes and attenuates dysfunctions related to lipid metabolism (2).
Lipolysis allows functional adipocytes to provide energy to other organs through hydrolysis of triglycerides stored in lipid vesicles, releasing fatty acids and glycerol. This process can be regulated by hormonal and biochemical signals acting on lipolytic enzymes (3). Isoprenalin and Caffeine are well-known regulators of lipolysis (4-6).