Skin redness is a sign of cutaneous inflammation which can lead to major skin disorders, like psoriasis or eczema. The mechanism of skin inflammation is complex and still not totally elucidated. When the skin is exposed to a stress, such as pathogens, allergens, irritants, or UV rays, cells produce a variety of inflammatory cytokines which bind to specific receptors on target cells. This binding stimulates the production of additional inflammatory signals, playing a key role in immune cell recruitment and activation.
NFκB translocation : does my active protect HaCaT keratinocytes against inflammation ?
Among the several inflammatory pathways, Nuclear Factor kappa B (NFκB) is a major protein transcription factor that orchestrates inflammation by its translocation from the cytoplasm to the cellular nucleus, allowing the expression of genes encoding inflammation proteins. This phenomenon could be assessed by immunostaining of NFκB.
IL-8 production : does my active protect HaCaT keratinocytes against inflammation ?
Among the cytokines produced in case of inflammation, Interleukin 8 (IL-8) is synthesized by epithelial cells following the detection of potentially pathogenic agents (microbiological or chemical). Its main role is to ensure the recruitment of phagocytic cells to the site of infection in order to eliminate them.