DNA damage (DNA breaks, DNA-adduct, epigenetics…), highly involved in cancer, can occur under different conditions:
- UV irradiation
- Pollution and various external aggressions (chemical aggression, smoke, …)
- Natural ageing
HCS Pharma has developed an automated 96-well plate assay for DNA damage assessment by using Comet analysis as an endpoint.
Here is an example of protection by N-Acetylcystein (NAC) against DNA damage induced by H2O2:
This assay allows to test if your molecules or active ingredients have a protection effect on oxidative DNA damage.
If you need more information, don’t hesitate to contact us!