Pharmacology


HCS main assets for pharmacology

Why have we decided to focus on cell imaging ?

1.  Because this technology allows phenotypic screening to discover new compounds and new targets for complex diseases, such as neurodegenerative diseases and cancer.

On 1178 FDA-approved drugs & 3074 experimental drugs, there are only 394 targets. But the network and regulation of these targets are huge.

Figure : Drug target network (Yildirim et al. (2007) Computational Biology 25(10): 1119-1126)

Figure : Drug target network (Yildirim et al. (2007) Computational Biology 25(10): 1119-1126)

Furthermore, complex diseases with multi-cellular and multi-target implication need multi-target drugs.

Figure: Distribution of drugs with respect to number of their targets. The FDA-approved drugs target 394 human proteins in total. Most drugs target only a few proteins, but some have many targets; for example, propiomazine (Largon) and promazine (Sparine) have 14 targets each, and olanzapine (Zyprexa, Zydis) and ziprasidone (Geodon) have 11 targets each. (Yildirim et al. (2007) Computational Biology 25(10): 1119-1126)

Figure: Distribution of drugs with respect to number of their targets. The FDA-approved drugs target 394 human proteins in total. Most drugs target only a few proteins, but some have many targets; for example, propiomazine (Largon) and promazine (Sparine) have 14 targets each, and olanzapine (Zyprexa, Zydis) and ziprasidone (Geodon) have 11 targets each. (Yildirim et al. (2007) Computational Biology 25(10): 1119-1126)

 

2. Because cellular imagery is a muti-parametric assay which enables to follow several parameters within the same experiment.

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