Many skin diseases, including psoriasis and basal cell carcinoma, are associated with microbial dysbiosis characterized by reduced C. acnes prevalence.

C. acnes is a facultative anaerobic bacterium that is frequently found on the human skin. This bacterium is both an opportunistic pathogen and a commensal organism. Indeed, most individuals are asymptomatic carriers, with colonizing bacteria that may even benefit their host.

Colonizing the skin requires the bacterium to tolerate oxygen and be able to protect itself from ROS (Reactive oxygen species). Researchers identified a novel antioxidant enzyme produced by C. acnes, called RoxP.

A recent study assessed the biological function of RoxP in vitro and in vivo, through oxidatively stressed cell cultures and through protein quantification from skin affected by oxidative disease. They showed that RoxP positively influence the viability of monocytes and keratinocytes exposed to oxidative stress, and that a concentration decline of RoxP can be detected in skin affected by oxidative disease.

This article demonstrates the utility of a healthy skin microbiome, in particular C. acnes due to its production of RoxP, in supporting redox homeostasis of human skin, thus protecting against development of several skin pathologies driven by oxidative stress.

Please do not hesitate to contact us, if you are interested in in vitro microbiota models.

Source : Common skin bacteria protect their host from oxidative stress through secreted antioxidant RoxP


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