Dans le cadre de notre développement, nous recrutons un(e) Technicien(ne) en recherche et développement axée sur des modèles hépatiques in vitro. Vous serez en charge de : Gestion du laboratoire (commandes, entretien des machines, règles HSE, gestion des stocks) Maintien des cultures cellulaires en routine (lignées, cellules primaires, cellules souches, etc…) Read more…
L’ingénieur(e) d’étude mettra au point des méthodes expérimentales permettant de développer un modèle tri-dimensionelle de tumeurs colorectales et de prostate avec la technologie Biomimesys développée par HCS Pharma. La technologie de culture BIOMIMESYS® 3D reproduit fidèlement le microenvironnement naturel des cellules d’un organe cible. Il est attendu un soutien conceptuel Read more…
We are very please to annonce our selection in the “CO-INNO INTERNATIONAL” program. Jointly organised by BPI France and Hello Tomorrow, the CO-INNO program accelerates and supports the most cutting-edge French startups from the discovery of the Singaporean ecosystem to the establishment of technological partnerships, funding and even their settlement Read more…
The current hiPSC-derived models are adapted to reproduce diseases of genetic origin in two dimensions and have allowed in recent years to model diseases by using hepatocyte-like-cells (HCL) such as: Alpha1-antitrypsin (A1AT) deficiency (Tafaleng et al., 2015) Familial transthyretin-related amyloidosis (ATTR) (Isono et al., 2014) Glycogen storage deficiency (Satoh et Read more…
When Tuesday, May 31, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, June 2, 2022 – 1PM (CEST) / 7PM (CST) / 8PM (JST) / 7AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as Read more…
When Tuesday, April 26, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, April 28, 2022 – 1PM (CEST) / 7PM (CST) / 8PM (JST) / 7AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as Read more…
Increased ExtraCellular Matrix (ECM) stiffness is a common process in many cancers (Pickup et al, 2014). This process influences the behaviour of cancer cells in the tumour microenvironment. The accumulation of ECM in the stroma is mainly due to a high production of ECM molecules by TGF-β(Transforming Growth Factor-beta) -stimulated Read more…
Historically, cancer has been described as originating from modified cells, because of mutations impacting their growth, their differentiation and their way (not) to die. Now, it is widely acknowledged that the microenvironment surrounding these cells is involved in cancer initiation and progression. As explained in the article by Nia Munn Read more…
Scanning Electron Microscopy (EM) has been an indispensable tool for Biological sciences. A great challenge was propelled by the need to find methods to better preserve and analyze structures at a state closest to the native state. With BIOMIMESYS® hydroscaffold technology, we have developed a new method to use SEM Read more…
HCS Pharma était présent au Workshop OoC pour une création et une structuration de la filière, organisé par Biovalley à l’Institut Pierre-Gilles de Gennes (Paris). Nous sommes très heureux d’avoir pu sponsoriser l’événement, mais aussi tout simplement d’y avoir participé – en présentiel – et de pouvoir discuter avec des chercheurs Read more…
The extracellular matrix (ECM) is a non-cellular component of tissues and organs. It is mainly composed of structural elements (proteoglycans collagens, elastin) and cell adhesion proteins such as fibronectin and laminins. The ECM forms a complex structure with physical properties (elasticity, tensile and compression strength), which provides physical support for Read more…
Ask for high quality link by putting your email below How to make in vitro models predictive of in vivo conditions? By taking into account the 3D cellular organization of in vivo tissues By including the cellular and matricial microenvironments with BIOMIMESYS® By using OoC systems for dynamic in vivo-like Read more…
2022 is beginning, but 2021 ended in the most beautiful way… with Véronique De Conto‘s PhD defense. She successfully defended her PhD thesis about the importance of the microenvironment in cerebral in vitro models for phenotypic screening. We had the privilege to maintain the PhD defense on-site, even if one member Read more…
Maintaining the basal characteristics of primary hepatocytes and HepG2 allows performing metabolic studies. The functional instability of hepatocytes in 2D culture results in a rapid decrease in specific metabolic pathways (Figure 1). Cell culture in BIOMIMESYS® Liver shows higher metabolic characteristics of hepatocytes compared to a culture in 2D, such Read more…
BIOMIMESYS® Liver recreates the complex cellular microenvironment of the liver to extend longevity and functionality of hepatocytes in culture: The life of human primary hepatocytes grown in a 2D sandwich is low, 3-10 days (1) and is accompanied by dedifferentiation, leading to the loss of their functions. In 2D culture, Read more…
In 2020, Nia et al. published in the journal Science a review entitled ‘Physical traits of cancer‘. In this article, the authors proposed 4 distinct physical traits of cancer linked to the biomechanical abnormalities observed in tumoral tissues : an enhanced solid stress (compression and tension), i.e. the mechanical forces Read more…
Hepatotoxicity testing in animals predicts only 50% of liver damage observed in clinical context, in part, because of difference in inter-species hepatic metabolism (1). Therefore, a relevant in vitro model mimicking the micro-environment of the human liver for maintaining and promoting hepatocyte functions, is needed for a better hepatotoxicity prediction Read more…
Pre-adipocytes differentiate into adipocytes through several phases: differentiation and maturation, where they are then completely functional (lipogenesis / lipolysis).
Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used Read more…
2D cell culture has been used for more than 100 years now, to keep cells outside of their original organism and to use them for different purposes. It is still widely used in research and early steps of the drug discovery process, and has allowed a bunch of discoveries so Read more…
The morphological changes in cells during differentiation are accompanied by a profound change at the molecular level. In vivo, the adipocyte differentiation process includes early and late events due to differential gene regulation. The appearance of these markers is a sign of differentiation of pre-adipocytes and hence the development of Read more…
This year, InnaSCo and Frontinov propose a joint scientific meeting dealing with inflammation, including presentations of prestigious speakers. This meeting will take place next week as a 2-day webinar, on the 20th and 21st October. The first day will be dedicated to quantitative biology approaches for exploration of inflammatory responses. This part of the Read more…
Triglycerides (TGs) are an efficient form of fatty acids to accumulate as energy reservoirs or as building blocks for membrane lipid synthesis. In adipose tissue, TGs are continuously synthesized during lipogenesis. In order to measure the lipogenesis activity of 3T3-L1 and mature human adipocytes, Adipored™ staining and Perilipin immunocytochemistry were Read more…