In October the expansion works started in HCS Pharma. The objective is to double the lab and office surface in the same building as our current premises, in the aim to expand BIOMIMESYS® production line to meet the growing demand while guaranteeing the quality of the products. These works will Read more…
Our project leader Méryl and our CBO Mathieu are currently attending CellME (Cell Manufacturing & Engineering) Forum taking place these days in Berlin, Germany. Méryl had the chance to present his work and the advantages of BIOMIMESYS® for organoid culture earlier today: Please feel free to discuss with them on Read more…
This is the end of the 6-month internship of Natacha in HCS Pharma, about the microenvironment modifications in Parkinson’s disease. Indeed, in vivo studies in the literature showed that the neuronal death in Parkinson’s disease involved Extracellular Matrix (ECM) modifications, including an increase in some components like collagen and a Read more…
Dear all, please feel free to contact Elodie who will be in RDV Carnot event in Paris (Espace Champerret, 17e arrondissement) tomorrow and on Thursday. Since HCS Pharma was selected as a laureate amongst innovative start-ups and SMEs for this ecent, she will be the first to pitch at 11:40 Read more…
About 90% of drug candidates fail in clinical trials, for efficacy- and toxicity-related reasons, which often involve the Central Nervous System (CNS). This high failure rate highlights a lack of relevance in experimental models used upstream, including human in vitro models. Indeed, they do not take into account the complexity Read more…
Our project director Elodie is participating to EUSAAT congress in Linz (Austria) this week, the European Congress on Alternatives to Animal Testing. She will have the pleasure to present our work aiming at bridging the gap between in vivo and in vitro situations by taking into account the extracellular matrix Read more…
Next month, we will have the pleasure to participate in the 23rd EUSAAT (EUropean Society for Alternative to Animal Testing) congress, which will take place in Linz (Austria) on the 26th-28th of September. We have proposed an abstract about how we use 3D in vitro cell culture models for recapitulating Read more…
The Federation of European Neuroscience Societies (FENS) forum 2022 took place in Paris, from 9 to 15 July. This event gathers nearly 8,000 neuroscientists from 92 countries. Twenty-two plenary and special lectures were given in 8 conferences room, about various topics in neurosciences, like brain imaging methods, brain development (synapse Read more…
Aim: About 90% of drug-candidates failed in clinical trials, in particular in neurology, due to a lack of efficacy. That highlights a lack of relevance in preclinical models, including in vitro models, which do not take into account the microenvironment, composed by glial cells and the Extracellular Matrix (ECM). The Read more…
Solid tumors are associated with a modified microenvironment, in particular an enhanced collagen content and increased stiffness at the level of the extracellular matrix (ECM). These ECM changes are now recognized as important drivers of cancer initiation, progression, and propagation, and also impact the responses of cancerous cells to treatments. Read more…
Dans le cadre de notre développement, nous recrutons un(e) Technicien(ne) en recherche et développement axée sur des modèles hépatiques in vitro. Vous serez en charge de : Gestion du laboratoire (commandes, entretien des machines, règles HSE, gestion des stocks) Maintien des cultures cellulaires en routine (lignées, cellules primaires, cellules souches, etc…) Read more…
L’ingénieur(e) d’étude mettra au point des méthodes expérimentales permettant de développer un modèle tri-dimensionelle de tumeurs colorectales et de prostate avec la technologie Biomimesys développée par HCS Pharma. La technologie de culture BIOMIMESYS® 3D reproduit fidèlement le microenvironnement naturel des cellules d’un organe cible. Il est attendu un soutien conceptuel Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this webinar we will focus on BIOMIMESYS® Liver and will discuss about its different applications. Read more…
We are very please to annonce our selection in the “CO-INNO INTERNATIONAL” program. Jointly organised by BPI France and Hello Tomorrow, the CO-INNO program accelerates and supports the most cutting-edge French startups from the discovery of the Singaporean ecosystem to the establishment of technological partnerships, funding and even their settlement Read more…
The current hiPSC-derived models are adapted to reproduce diseases of genetic origin in two dimensions and have allowed in recent years to model diseases by using hepatocyte-like-cells (HCL) such as: Alpha1-antitrypsin (A1AT) deficiency (Tafaleng et al., 2015) Familial transthyretin-related amyloidosis (ATTR) (Isono et al., 2014) Glycogen storage deficiency (Satoh et Read more…
When Tuesday, May 31, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, June 2, 2022 – 1PM (CEST) / 7PM (CST) / 8PM (JST) / 7AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). BIOMIMESYS® hydroscaffold technology based on crosslinking Hyaluronic Acid (HA) and extracellular matrix compounds reproduces tissue microenvironment Read more…
When Tuesday, April 26, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, April 28, 2022 – 1PM (CEST) / 7PM (CST) / 8PM (JST) / 7AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as Read more…
Increased ExtraCellular Matrix (ECM) stiffness is a common process in many cancers (Pickup et al, 2014). This process influences the behaviour of cancer cells in the tumour microenvironment. The accumulation of ECM in the stroma is mainly due to a high production of ECM molecules by TGF-β(Transforming Growth Factor-beta) -stimulated Read more…
Historically, cancer has been described as originating from modified cells, because of mutations impacting their growth, their differentiation and their way (not) to die. Now, it is widely acknowledged that the microenvironment surrounding these cells is involved in cancer initiation and progression. As explained in the article by Nia Munn Read more…
Scanning Electron Microscopy (EM) has been an indispensable tool for Biological sciences. A great challenge was propelled by the need to find methods to better preserve and analyze structures at a state closest to the native state. With BIOMIMESYS® hydroscaffold technology, we have developed a new method to use SEM Read more…
HCS Pharma était présent au Workshop OoC pour une création et une structuration de la filière, organisé par Biovalley à l’Institut Pierre-Gilles de Gennes (Paris). Nous sommes très heureux d’avoir pu sponsoriser l’événement, mais aussi tout simplement d’y avoir participé – en présentiel – et de pouvoir discuter avec des chercheurs Read more…
The extracellular matrix (ECM) is a non-cellular component of tissues and organs. It is mainly composed of structural elements (proteoglycans collagens, elastin) and cell adhesion proteins such as fibronectin and laminins. The ECM forms a complex structure with physical properties (elasticity, tensile and compression strength), which provides physical support for Read more…