Développement d’un modèle cérébral in vitro en 3 dimensions (présentation au congrès de la SCMC)

Véronique De Conto, doctorante chez HCS Pharma, présentera ce jeudi 28 mars à Lille, au congrès annuel de la Société Cerveau et Maladies Cérébrovasculaires, le développement d’un modèle cérébral en 3 dimensions incluant le microenvironnement matriciel pour la recherche de nouveaux médicaments contre la maladie de Parkinson. Introduction : 90% Read more…

Poster – Characterisation of 3D cultured primary human hepatocytes and HepaRG for DMSO-free preclinical toxicity testing

Hepatocytes in primary cultures are still the gold standard in the pharmaceutical industry ; however they are expensive and have a very short lifespan with a progressive loss of specific functions over time. The dipolar aprotic solvent, dimethyl sulfoxide (DMSO) is wildly used to stabilize the liver specific function of Read more…

Drug discovery : Need of reliable IVIVE for pharmacodynamics and pharmacokinetics assessment

For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…